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The prevalence of nonalcoholic steatohepatitis in the United States approaches that of type 2 diabetes, and annual medical costs directly attributable to nonalcoholic fatty liver disease already exceed $100 billion, much of which is attributable to nonalcoholic steatohepatitis, underscoring the importance of developing interventions to prevent and treat this disease
Insulin therapy, delivered via subcutaneous (SC) injections or continuous subcutaneous insulin infusion (CSII) systems, remains indispensable, particularly in individuals with T1DM and those with progressive or inadequately controlled T2DM
The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE(/) mice by blocking monocyte/macrophage activation
M., de Campos Vieira Abib, A., de Moura, D
Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, and Egan JM
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